The men’s and women’s entry list for the 2022 Miami Open can be found below. The event takes place from March 21 – April 3, 2022.
ATP Acceptance List (as of February 22, 2022)
| Rank | First | Last | COU |
| 1 | Novak | Djokovic | SRB |
| 2 | Daniil | Medvedev | RUS |
| 3 | Alexander | Zverev | GER |
| 4 | Stefanos | Tsitsipas | GRE |
| 5 | Rafael | Nadal | ESP |
| 6 | Matteo | Berrettini | ITA |
| 7 | Andrey | Rublev | RUS |
| 8 | Casper | Ruud | NOR |
| 9 | Felix | Auger-Aliassime | CAN |
| 10 | Jannik | Sinner | ITA |
| 11 | Hubert | Hurkacz | POL |
| 12 | Cameron | Norrie | GBR |
| 13 | Diego | Schwartzman | ARG |
| 14 | Denis | Shapovalov | CAN |
| 15 | Roberto | Bautista Agut | ESP |
| 16 | Taylor | Fritz | USA |
| 17 | Pablo | Carreno Busta | ESP |
| 18 | Reilly | Opelka | USA |
| 19 | Nikoloz | Basilashvili | GEO |
| 20 | Carlos | Alcaraz | ESP |
| 21 | Lorenzo | Sonego | ITA |
| 22 | Aslan | Karatsev | RUS |
| 23 | John | Isner | USA |
| 24 | Marin | Cilic | CRO |
| 25 | Gael | Monfils | FRA |
| 26 | Karen | Khachanov | RUS |
| 27(PR) | Borna | Coric | CRO |
| 27 | Cristian | Garin | CHI |
| 28 | Daniel | Evans | GBR |
| 30 | Alexander | Bublik | KAZ |
| 31 | Albert | Ramos-Vinolas | ESP |
| 32 | Alex | de Minaur | AUS |
| 33 | Grigor | Dimitrov | BUL |
| 34 | Frances | Tiafoe | USA |
| 35 | Lloyd | Harris | RSA |
| 36 | Marton | Fucsovics | HUN |
| 37 | Federico | Delbonis | ARG |
| 38 | Fabio | Fognini | ITA |
| 39 | Tommy | Paul | USA |
| 40 | Sebastian | Korda | USA |
| 41 | Ugo | Humbert | FRA |
| 43 | Alejandro | Davidovich Fokina | ESP |
| 44 | Filip | Krajinovic | SRB |
| 45 | Ilya | Ivashka | BLR |
| 46 | Dusan | Lajovic | SRB |
| 47 | Jenson | Brooksby | USA |
| 48 | David | Goffin | BEL |
| 49 | Benoit | Paire | FRA |
| 50 | Botic | van de Zandschulp | NED |
| 51 | Laslo | Djere | SRB |
| 52 | Dominic | Thiem | AUT |
| 53 | Arthur | Rinderknech | FRA |
| 54 | Dominik | Koepfer | GER |
| 55 | Adrian | Mannarino | FRA |
| 56 | Jan-Lennard | Struff | GER |
| 57 | Tallon | Griekspoor | NED |
| 58 | Lorenzo | Musetti | ITA |
| 59 | Marcos | Giron | USA |
| 60 | Soonwoo | Kwon | KOR |
| 61 | Mackenzie | McDonald | USA |
| 62 | Federico | Coria | ARG |
| 63 | Miomir | Kecmanovic | SRB |
| 64 | Benjamin | Bonzi | FRA |
| 65 | James | Duckworth | AUS |
| 66 | Alexei | Popyrin | AUS |
| 67 | Maxime | Cressy | USA |
| 68 | Pablo | Andujar | ESP |
| 68(PR) | Jo-Wilfried | Tsonga | FRA |
| 69 | Alex | Molcan | SVK |
| 69(PR) | Gilles | Simon | FRA |
| 70 | Hugo | Gaston | FRA |
| 71 | Emil | Ruusuvuori | FIN |
| 72 | Pedro | Martinez | ESP |
| 73 | Richard | Gasquet | FRA |
| 74 | Facundo | Bagnis | ARG |
| 75 (PR) | Aljaz | Bedene | SLO |
| 75 | Brandon | Nakashima | USA |
| 76 | Francisco | Cerundolo | ARG |
| 77 | Kamil | Majchrzak | POL |
| 78 | Sebastian | Baez | ARG |
| 79 | Juan Manuel | Cerundolo | ARG |
| 89 (WC) | Andy | Murray | GBR |
| 137 (WC) | Nick | Kyrgios | AUS |
WTA Acceptance List (as of February 22, 2022)
| Rank | First | Last | COU |
| 1 | Ashleigh | Barty | AUS |
| 2 | Aryna | Sabalenka | BLR |
| 3 | Barbora | Krejcikova | CZE |
| 4 | Paula | Badosa | ESP |
| 5 | Karolina | Pliskova | CZE |
| 6 | Maria | Sakkari | GRE |
| 7 | Anett | Kontaveit | EST |
| 8 | Iga | Swiatek | POL |
| 9 | Garbiñe | Muguruza | ESP |
| 10 | Ons | Jabeur | TUN |
| 11 | Danielle | Collins | USA |
| 12 | Emma | Raducanu | GBR |
| 13 | Jelena | Ostapenko | LAT |
| 14 | Anastasia | Pavlyuchenkova | RUS |
| 15 | Elina | Svitolina | UKR |
| 16 | Victoria | Azarenka | BLR |
| 17 | Jessica | Pegula | USA |
| 18 | Angelique | Kerber | GER |
| 19 | Leylah | Fernandez | CAN |
| 20 | Elena | Rybakina | KAZ |
| 21 | Petra | Kvitova | CZE |
| 22 | Belinda | Bencic | SUI |
| 23 | Cori | Gauff | USA |
| 24 | Tamara | Zidansek | SLO |
| 25 | Veronika | Kudermetova | RUS |
| 26 | Elise | Mertens | BEL |
| 27 | Simona | Halep | ROU |
| 28 | Daria | Kasatkina | RUS |
| 29 | Madison | Keys | USA |
| 30 | Camila | Giorgi | ITA |
| 31 | Sorana | Cirstea | ROU |
| 32 | Sara | Sorribes Tormo | ESP |
| 33 | Clara | Tauson | DEN |
| 34 | Liudmila | Samsonova | RUS |
| 35 | Marketa | Vondrousova | CZE |
| 36 | Viktorija | Golubic | SUI |
| 37 | Alizé | Cornet | FRA |
| 38 | Ajla | Tomljanovic | AUS |
| 39 | Yulia | Putintseva | KAZ |
| 40 | Amanda | Anisimova | USA |
| 41 | Jil | Teichmann | SUI |
| 42 | Tereza | Martincova | CZE |
| 43 | Jasmine | Paolini | ITA |
| 44 | Camila | Osorio | COL |
| 45 | Shelby | Rogers | USA |
| 46 | Nuria | Parrizas Diaz | ESP |
| 47 | Katerina | Siniakova | CZE |
| 48 | Anhelina | Kalinina | UKR |
| 49 | Ekaterina | Alexandrova | RUS |
| 50 | Ana | Konjuh | CRO |
| 51 | Alison | Riske | USA |
| 52 | Alison | Van Uytvanck | BEL |
| 53 | Marta | Kostyuk | UKR |
| 54 | Irina-Camelia | Begu | ROU |
| 55 | Elena-Gabriela | Ruse | ROU |
| 57 | Sloane | Stephens | USA |
| #57 | Laura | Siegemund | GER |
| 58 | Ann | Li | USA |
| 59 | Andrea | Petkovic | GER |
| 60 | Madison | Brengle | USA |
| 61 | Aliaksandra | Sasnovich | BLR |
| 62 | Karolina | Muchova | CZE |
| 63 | Kaia | Kanepi | EST |
| 64 | Mayar | Sherif | EGY |
| 65 | Shuai | Zhang | CHN |
| 66 | Arantxa | Rus | NED |
| 67 | Magda | Linette | POL |
| 68 | Danka | Kovinic | MNE |
| 69 | Maryna | Zanevska | BEL |
| 70 | Beatriz | Haddad Maia | BRA |
| 71 | Jaqueline | Cristian | ROU |
| 72 | Varvara | Gracheva | RUS |
| 73 | Rebecca | Peterson | SWE |
| 74 | Clara | Burel | FRA |
| 75 | Kristina | Kucova | SVK |
| 76 | Caroline | Garcia | FRA |
| 77 | Qinwen | Zheng | CHN |
| 82 (WC) | Naomi | Osaka | JPN |
